Tuesday, 3 September 2013

Prof Dan Bradley - DNA and the Irish past

Name - Professor Daniel Bradley
              Professor of Genetics, TCD

Membership 
  • Member of International Society of Animal Genetics 
  • Member of the Royal Irish Academy
  • Five times juror in the European Contest for Young Scientists 
  • Fellow of Trinity College Dublin

Position - Dan holds a Personal Chair in the Smurfit Institute of Genetics, Trinity College Dublin, and has written or co-authored over 110 publications including many in premier journals (e.g. Science, PNAS, Nature) – see Publications below.

Involvement with genetic genealogy?
Dan has researched in the following areas: 
  • Y chromosome diversity, Irish medeival genealogies, and the genetic architecture of Irish surnames
  • Irish human population structure
  • Ancient DNA
  • Detection of signatures of selection in human, bovine, salmon and chicken genomes
  • Origins of livestock as discerned using genetic diversity
  • Genetic basis of disease resistance in cattle

So what will be the topic of the presentation?
Dan will be talking about the work of his unit in Trinity College Dublin with particular reference to the seminal work relating to the Y-DNA haplotype correlation with Niall of the Nine Hostages.

What DNA tests will be discussed?
Primarily Y-DNA

To what surnames is this topic relevant?
O'Neill, and surnames associated with the Ui Neill dynasty - McLaughlin, O'Cathain, McShane, O’Donnell, Bradley, O’Gallagher, O’Doherty, Flynn, McLaughlin, Byrne, etc

Where can people get more information?
For more information just click on the links below:

Publications relevant to genetic genealogy - 
  • Busby GB, et al. The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269. Proc Biol Sci. 2011 Aug 24. [Epub ahead of print]. PMID:21865258Direct link
  • Tong P, et al. Sequencing and analysis of an Irish human genome Genome Biol. 2010 Sep 7;11(9) PMID: 20822512.
  • Mattiangeli V, McEvoy B, Bradley DG. Irish genetic affinities : the mosaic genome.Ir Nat J Spec Suppl. 2008; pg127-133.
  • McEvoy B, Simms K, Bradley DG. Genetic investigation of the patrilineal kinship structure of early medieval Ireland. Am J Phys Anthropol. 2008 Aug;136(4):415-22. Epub 2008 Mar 18. PMID: 18350585
  • Bauchet M, et al. Measuring European population stratification with microarray genotype data. Am J Hum Genet. 2007 May;80(5):948-56. Epub 2007 Mar 22. PMID: 17436249
  • Norton HL, et al. Genetic evidence for the convergent evolution of light skin in Europeans and East Asians. Mol Biol Evol. 2007 Mar;24(3):710-22. Epub 2006 Dec 20. PMID: 17182896
  • McEvoy B, Brady C, Moore LT, Bradley DG. The scale and nature of Viking settlement in Ireland from Y-chromosome admixture analysis. Eur J Hum Genet. 2006 Dec;14(12):1228-94. Epub 2006 Sep 6. PMID: 16957681
  • Mattiangeli V, Ryan AW, McManus R, Bradley DG. A genome-wide approach to identify genetic loci with a signature of natural selection in the Irish population.Genome Biol. 2006;7(8):R74. Epub 2006 Aug 11. PMID: 16904005
  • McEvoy B, Bradley DG. Y-chromosomes and the extent of patrilineal ancestry in Irish surnames. Hum Genet. 2006 Mar;119(1-2):212-9. Epub 2006 Jan 12. PMID: 16408222
  • Moore LT, McEvoy B, Cape E, Simms K, Bradley DG. A y-chromosome signature of hegemony in gaelic ireland. Am J Hum Genet. 2006 Feb;78(2):334-8. Epub 2005 Dec 8. PMID: 16358217
  • McEvoy B, Richards M, Forster P, Bradley DG. The Longue Duree of genetic ancestry: multiple genetic marker systems and Celtic origins on the Atlantic facade of Europe. Am J Hum Genet. 2004 Oct;75(4):693-702. Epub 2004 Aug 12.PMID: 15309688
  • Edwards CJ, Connellan J, Wallace PF, Park SD, McCormick FM, Olsaker I, Eythorsdottir E, MacHugh DE, Bailey JF, Bradley DG. Feasibility and utility of microsatellite markers in archaeological cattle remains from a Viking Age settlement in Dublin. Anim Genet. 2003 Dec;34(6):410-6. PMID: 14687070
  • Hill EW, Jobling MA, Bradley DG. Y-chromosome variation and Irish origins.Nature. 2000 Mar 23;404(6776):351-2. PMID: 10746711
  • Rosser ZH, et al. Y-Chromosomal Diversity in Europe Is Clinal and Influenced Primarily by Geography, Rather than by Language. Am J Hum Genet. 2000 Dec;67(6):1526-1543. PMID: 11078479
  • Helgason A, et al. Estimating Scandinavian and Gaelic ancestry in the male settlers of Iceland. Am J Hum Genet. 2000 Sep;67(3):697-717. PMID: 10931763

Publications from the unit at TCD - http://www.gen.tcd.ie/molpopgen/publications.php

The lectures were sponsored by FamilyTreeDNA and organised by ISOGG (International Society of Genetic Genealogy).




1 comment:

  1. Surprising that Bradley is still refering to this publication:-
    McEvoy B, Simms K, Bradley DG. "Genetic investigation of the patrilineal kinship structure of early medieval Ireland." Am J Phys Anthropol. 2008 Aug;136(4):415-22. Epub 2008 Mar 18. PMID: 18350585

    It was incorrect when published and refuted in 2009.
    Wright D "A Set of Distinctive Markers Defines a Y-STR Signature for Gaelic Dalcassian Families" Journal of Genetic Genealogy - Spring 2009 - http://jogg.info/51/files/Wright.pdf

    Dennis Wright

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